Abstract :Objective To investigate the effect of epidermal growth factor (rhEGF) combined with Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment) on wound scars in patients with deep second-degree burns. Methods A total of 113 patients with deep second-degree burns admitted to Ankang Central Hospital from January 2017 to January 2018 were selected as the research subjects and divided into an observation group (n=56) and a control group (n=57) according to the random number table method. All patients were given conventional debridement treatment. The control group was treated with rh EGF applied to the wound surface, and the observation group was treated with rh EGF combined with Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment) applied to the wound surface. The treatment course of both groups was 28 days. The wound healing, bacterial detection, scar formation and adverse reactions during medication were compared between the two groups after treatment. Results The dry time of deep II burn wounds in the observation group [(6.51±2.62) d vs (9.62±3.51) d], healing time [(19.52±3.73) d vs (25.85±5.95) d], and dressing changes [(12.65±5.34) vs (17.51±6.72)] were significantly shorter in the observation group than in the control group (P<0.05). The wound healing rate in the observation group was (95.26±2.37)%, which was significantly higher than that in the control group (83.12±3.65)%, with a statistically significant difference (P<0.05). The wound healing rate in the observation group was (95.26±2.37)%, which was significantly higher than that in the control group (83.12±3.65)%, with a statistically significant difference (P<0.05). The wound healing rate in the observation group was (95.26±2.37)% after medication for 7 days, 14 days, and 28 days. The detection rates of pathogens in deep II burn wounds were 17.86%, 12.50% and 5.36% respectively, which were significantly lower than those in the control group (36.84%, 28.07% and 17.54%), with significant differences (P<0.05). The modified Vancouver Scar Scale (VSS) scores of the observation group were lower than those of the control group at 28 days [(7.25±2.16) points vs (8.66±2.54) points], 6 months [(5.38±1.94) points vs (7.03±2.11) points], and 12 months [(3.25±1.02) points vs (4.95±1.48) points] after medication, with significant differences (P<0.05). The incidence of wound infection in the observation group was 0, which was significantly lower than that in the control group (8.77%), with significant differences (P<0.05). Conclusion rhEGF combined with Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment) can promote the healing of deep second-degree burn wounds, reduce wound infection, and reduce scar tissue formation.
Chen Zechun, Li Jun, Chen Tao. Effect of epidermal growth factor combined with polymyxin B on scars of deep second-degree burn wounds[J]. Hainan Medical Journal, 2019, 30(15): 1947-1949.