Abstract :Objective To analyze the application of Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) in patients with burns in the intensive care unit and provide a reference for the selection of burn treatment plans. Methods A total of 243 burn patients admitted to the burn intensive care unit of the burn department of Beijing Jishuitan Hospital from January 2015 to December 2019 were selected as the research subjects. The specific use of compound polymyxin B in patients with different burn areas was compared, and the liver function indicators [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] and renal function indicators (urea, creatinine) of patients using and not using compound polymyxin B were compared. The total treatment cost of patients with different burn areas using and not using Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) was compared. Results The bacterial flora in the wound exudate of 243 patients was analyzed and it was found that bacteria were detected in the wound of 172 patients, with Pseudomonas aeruginosa being the most detected (27.91%, 48/172), followed by Acinetobacter baumannii (14.53%, 25/172), Klebsiella pneumoniae (9.88%, 17/172) and Staphylococcus aureus (9.30%, 16/172) ranking third and fourth respectively. Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) was sensitive to most of the detected bacterial flora. The maximum amount of Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) used by a single burn patient during hospitalization was 492 tubes, and the maximum amount used at a single time was 13 tubes. Among the 243 patients, 219 patients used Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) and 24 patients did not use it. There was no statistically significant difference in the levels of ALT, AST, urea and creatinine between patients who used and did not use Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) ( P>0.05). The total treatment cost of patients with burn area ≤10% who used Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) was lower than that of the non-use group, and the average daily treatment cost of the former was 4% of the latter. Conclusion Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) has high safety in burn treatment, is sensitive to the bacterial flora of burn wound infection, can effectively control infection and promote wound recovery, especially for local use in the treatment of patients with small area burns, which can greatly reduce the treatment cost.
Wang Cheng, Bian Jing, Shen Yuming. Analysis of local use of compound antibiotic preparations in the treatment of burn patients [J]. Journal of Clinical Military Medicine, 2022, 50(06): 612-615.