本研究旨在比较外用药物对上海某医院患者分离出的痤疮丙酸杆菌的抗菌活性。根据临床和实验室标准研究所确定培养的痤疮丙酸杆菌的最低抑菌浓度。比较了性别、年龄、病程、既往治疗和疾病严重程度对克林霉素和红霉素的敏感性。从 98 名患者（70.41%）中分离出 69 株痤疮丙酸杆菌菌株。对三联抗生素软膏（新霉素/杆菌肽/多粘菌素 B）和杆菌肽的敏感性为 100%。对夫西地酸的敏感性为 92.7%。对硫酸新霉素、红霉素和克林霉素的耐药率分别为 11.7%、49.3% 和 33.4%。克林霉素和红霉素的高耐药率与性别、既往治疗及病情严重程度相关，与年龄及病程无关；局部用药不宜单独长期治疗，以免产生多重耐药，局部用药应由临床医生根据临床情况决定。
Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.
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Antimicrobial activity of topical agents.pdf